Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable - for protection against: Heartworm disease. Ticks* & fleas. Roundworms & hookworms.

Simparica is a veterinary medicine used to treat infestations with ticks and fleas, demodectic and sarcoptic mange (skin infestations caused by two different types of mites) and ear mite infestations in dogs. After Simparica is given its activity against ticks and fleas lasts for at least 5 weeks.

Simparica Trio is a once-a-month chewable that protects your dog with three proven ingredients designed for defense. It's available from your vet with a prescription and comes with a 100% satisfaction guarantee. Protects dogs against heartworm disease, ticks & fleas, roundworms & hookworms.

Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders.

How Simparica® & Simparica Trio® Works. The active ingredient of Simparica®, sarolaner, belongs to a newer class of flea and tick preventatives called isoxazolines. Sarolaner is ingested by fleas and ticks when they bite, and works by over-exciting their nervous system, causing paralysis and death.

Simparica Trio is considered safe for dogs as young as eight weeks old who weigh at least 2.8 pounds. However, the product has not been evaluated in breeding, pregnant, or lactating dogs.

Simparica Trio is considered safe for dogs as young as eight weeks old who weigh at least 2.8 pounds. However, the product has not been evaluated in breeding, pregnant, or lactating dogs.

For flea or tick infestations, one treatment with Simparica Trio is effective for up to 5 weeks. Further flea or tick treatment should be continued using a different veterinary medicine with a narrower range of action. To prevent lungworm and heartworm disease for one month, a single treatment is required.

We routinely recommend using Nexgard and Simparica for our patients and continue to believe that the medications in this class of drugs are safe for the majority of pets so we wanted to go over a few things about these medications to hopefully address concerns you may have about using them.

It's best to keep your dog on tick and flea preventive medication year-round since you never know when a thaw will be warm enough to allow ticks to be active again.

You can use Simparica Flea and Tick Medication monthly to keep your dogs safe from these pesky parasites. This medicine protects your dog for 35 days, after which you can give your dog another dose.

Yes, Simparica Trio is FDA-approved and often has a generally positive response with dogs.

Zoetis Receives FDA Approval for Simparica Trio™, A New Combination Parasite Preventative for Dogs. First combination isoxazoline for dogs in the U.S.