EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1-6 infection with or without cirrhosis (compensated). In those with advanced cirrhosis (decompensated), EPCLUSA is used with ribavirin.

EPCLUSA contains the two medicines: sofosbuvir and velpatasvir. It is not known if EPCLUSA is safe and effective in children under 3 years of age. Medication Guide for important pregnancy, contraception, and infertility information.

In clinical studies, EPCLUSA was proven effective in treating chronic Hep C patients who had previously failed a peginterferon alfa- and ribavirin-based regimen, with or without a protease inhibitor. Protease inhibitors are a class of antiviral drugs used to treat Hep C and work by stopping the virus from replicating.

Epclusa is a brand-name medication that's also available as the generic drug sofosbuvir/velpatasvir. A generic drug is an exact copy of the active drug in a brand-name medication. A generic is considered to be just as safe and effective as the original drug.

How does Epclusa work? Epclusa directly blocks the ability of the hepatitis C virus to make copies of itself in the liver. Sofosbuvir interferes with the reproduction of the genetic material of the hepatitis C virus and velpatasvir works by interfering with a protein needed by the virus.

Bottom Line. Epclusa has a 98% overall cure rate in all 6 of the main types of hepatitis C in patients without cirrhosis (a serious liver disease) or with compensated cirrhosis (mild or no symptoms).

Epclusa is manufactured and marketed by Gilead Sciences, Inc., of Foster City, California.

How does Epclusa work? Epclusa directly blocks the ability of the hepatitis C virus to make copies of itself in the liver. Sofosbuvir interferes with the reproduction of the genetic material of the hepatitis C virus and velpatasvir works by interfering with a protein needed by the virus.

Bottom Line. Epclusa has a 98% overall cure rate in all 6 of the main types of hepatitis C in patients without cirrhosis (a serious liver disease) or with compensated cirrhosis (mild or no symptoms).

Company: Gilead Sciences, Inc.

EPCLUSA can cause serious side effects, including: If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA.

EPCLUSA can cause serious side effects, including: If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA.

Company: Gilead Sciences, Inc.