Trintellix is an oral tablet that is taken once a day. May be taken with or without food. Trintellix is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibits serotonin reuptake.

Trintellix is a doctor-prescribed SSRI-type antidepressant medication used in treating major depressive disorder in adults as young as age 18 and up. Trintellix was designed to influence the serotonin neurotransmitter, and possibly other areas of neurochemistry.

Trintellix has an average rating of 6.0 out of 10 from a total of 442 reviews on Drugs.com. 47% of reviewers reported a positive experience, while 34% reported a negative experience.

Mechanism of action1 The mechanism of the antidepressant effect of TRINTELLIX is not fully understood, but it is thought to be related to its enhancement of serotonergic activity in the central nervous system through inhibition of the reuptake of serotonin (5-HT).

Trintellix is only available as a brand-name drug. It doesn't come in a generic version. A generic drug is an exact copy of the active drug in a brand-name medication. Generics tend to cost less than brand-name drugs.

Trintellix has an average rating of 6.0 out of 10 from a total of 415 reviews for the treatment of Major Depressive Disorder. 48% of reviewers reported a positive experience, while 34% reported a negative experience.

Trintellix (vortioxetine) may increase your risk of suicidal thoughts or behavior, especially in people under the age of 25. Watch out for worsening depression or any unusual changes in your mood or behavior, especially during the first few months of treatment or with a dose change.

Common side effects of Trintellix include:

• nausea.
• diarrhea.
• dry mouth.
• constipation.
• vomiting.
• gas.
• dizziness.
• abnormal dreams.

Trintellix (vortioxetine) may increase your risk of suicidal thoughts or behavior, especially in people under the age of 25. Watch out for worsening depression or any unusual changes in your mood or behavior, especially during the first few months of treatment or with a dose change.

This medication has a boxed warning from the Food and Drug Administration (FDA). This is the strongest warning that the FDA requires. A boxed warning alerts doctors and patients about drug effects that may be dangerous. Trintellix can increase the risk of suicidal thoughts and actions in children and young adults.

Important Safety Information TRINTELLIX may cause serious side effects, including serotonin syndrome, increased risk of bleeding, hypomania (manic episodes), discontinuation syndrome (side effects if you suddenly stop taking TRINTELLIX), visual problems, low levels of salt in your blood, or sexual problems.

Common side effects of Trintellix include:

• nausea.
• diarrhea.
• dry mouth.
• constipation.
• vomiting.
• gas.
• dizziness.
• abnormal dreams.

Important Safety Information TRINTELLIX may cause serious side effects, including serotonin syndrome, increased risk of bleeding, hypomania (manic episodes), discontinuation syndrome (side effects if you suddenly stop taking TRINTELLIX), visual problems, low levels of salt in your blood, or sexual problems.