Trintellix may be used to treat major depressive disorder (MDD) in adults. Although not FDA-approved to treat anxiety, Trintellix has been used off-label to treat generalized anxiety disorder (GAD). It appears to work best in those with severe GAD (HAMA of >25). Trintellix is an oral tablet that is taken once a day.

Trintellix is only available as a brand-name drug. It doesn't come in a generic version. A generic drug is an exact copy of the active drug in a brand-name medication. Generics tend to cost less than brand-name drugs.

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The mechanism of the antidepressant effect of TRINTELLIX is not fully understood, but it is thought to be related to its enhancement of serotonergic activity in the central nervous system through inhibition of the reuptake of serotonin (5-HT).

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TRINTELLIX started offering relief from depression symptoms as early as week 2 and lasted long-term. In short-term studies (6-8 weeks) based on a standardized depression rating scale, the therapeutic effect of TRINTELLIX was generally seen starting at week 2, with full effect generally not seen until week 4, or later.

Important Safety Information TRINTELLIX may cause serious side effects, including serotonin syndrome, increased risk of bleeding, hypomania (manic episodes), discontinuation syndrome (side effects if you suddenly stop taking TRINTELLIX), visual problems, low levels of salt in your blood, or sexual problems.

The half-life of Trintellix is about 66 hours. A drug's half-life is the amount of time it takes for your body to get rid of half of a drug's dose.

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How long does it take for TRINTELLIX to start working? The therapeutic effect of TRINTELLIX was generally seen starting at week 2, while the full antidepressant effect was generally not seen until week 4, or later. These results were based on a standardized depression rating scale in 6‑ to 8‑week studies.

Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.