NUPLAZID® is an FDA-approved treatment for hallucinations and delusions associated with Parkinson's disease psychosis.

The common side effects of NUPLAZID include swelling in the legs or arms, nausea, confusion, hallucination, constipation, and changes to normal walking. These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider about this medicine.

Pimavanserin (Nuplazid™) is an atypical antipsychotic currently indicated for the treatment of hallucinations and delusions associated with Parkinson disease psychosis. The antipsychotic effects of this new agent are believed to occur via selective inverse agonist activity at serotonin 5-HT2a receptors.

The cost for Nuplazid oral capsule 34 mg is around $5,269 for a supply of 30 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.

The introduction of Rivastigmine led to improvement in cognitive and functional abilities as well as resolution of behavioral problems and visual hallucinations. As indicated in some researches, Rivastigmine, Donepezil, Galantamine are some ChEIs that may be effective in the treatment of visual hallucination (7, 14).

NUPLAZID may begin to reduce hallucinations and delusions as soon as 4 weeks, but it may take up to 6 weeks to feel the full effect.

In one study, 10% of those with minor hallucinations had their symptoms resolved within a few years, while 52% saw their symptoms remain the same and 38% saw their psychosis symptoms get worse. We recommend that people with Parkinson's not use a single percentage to represent the prevalence of hallucinations and PDP.

Hallucinations and delusions usually happen in the later stages of Parkinson's. They can affect both younger and older people in the earlier stages of the condition, but this is less common.

It's not likely that Nuplazid will worsen your hallucinations, but it can happen. In clinical trials: 5% of people taking Nuplazid experienced hallucinations. 3% of people taking a placebo (a treatment with no active drug) experienced hallucinations.

Cons and Complications. The most common side effects of Nuplazid are leg swelling, nausea and confusion. Like all antipsychotic medications, Nuplazid carries a "black box" warning of the potential for increased risk of death in elderly people with dementia (significant memory and/or thinking problems).

Due to damage in the mid-brain (peduncular hallucinosis) They may disappear within a few weeks, but sometimes carry on for longer. Each hallucination may last for several minutes or up to several hours, and they often occur in the evening.