The biggest difference between these medications is that K9 Advantix II kills AND repels fleas, ticks, mosquitoes, and chewing lice, but Frontline Plus kills these pests AND prevents fleas from laying new eggs. Pregnant dogs are also approved to use Frontline Plus, and vets must be consulted to use K9 Advantix II.

Advantage II is available in a feline formula as well, while K9 Advantix II is made only for dogs. Advantage II contains Pyriproxyfen and Imidacloprid. K9 Advantix II combines the active ingredients of Pyriproxyfen, Imidacloprid, and Permethrin.

The insect growth regulator, which is known as pyriproxyfen, was added to the formula to make it a more complete flea and tick killing solution. The IGR ingredient makes it possible to kill fleas and ticks in all of their life stages. This is the main difference between regular K9 Advantix and K9 Advantix II.

Effective flea treatment kills 98-100% of the fleas on dogs within 12 hours and continues to prevent infestations for at least four weeks and kills fleas before they lay eggs. Larval flea stages in the dog's surroundings are killed following contact with a K9 Advantix II.

K9 Advantix II Extra Large Dog is the veterinarian-recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes.

K9 Advantix II is a top veterinarian-recommended brand because it repels and kills all life stages of fleas (eggs, pupae, larvae, and adult fleas) and ticks (Deer ticks, American dog ticks, Brown dog ticks, and Lone Star ticks).

within 12 hours How long does it take for K9 Advantix® II to work on fleas? K9 Advantix® II kills fleas within 12 hours. New fleas that jump on the dog from the surroundings, such as grass, carpet and pet bedding, are killed within 2 hours with protection against further infestation for at least 4 weeks.

Side Effects: Monitor your dog after application. Side effects, although very rare, may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as vomiting or diarrhea have also been reported.

Side Effects: Monitor your dog after application. Side effects, although very rare, may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as vomiting or diarrhea have also been reported.

A single application of K9 Advantix II remains effective for four weeks. However, if the dog has a severe infestation, retreatment within a month may be necessary. Do not retreat more than once every seven days not to exceed weekly treatments.

about 1-5 hours Once the Advantix Plus has been fully absorbed by your dog's skin and coat and the treated area is dry, it is generally safe for other people and animals to touch your dog. This usually takes about 1-5 hours, depending on factors such as the humidity and temperature of the environment.

Frontline Plus Our top choice for an OTC flea preventive is Frontline Plus, which also protects against chewing lice and helps control sarcoptic mange infestations. Compared to Frontline Plus, NexGard kills fleas more quickly (4 hours versus 12 hours) and ticks (24 hours versus 48 hours).