Duloxetine is used to treat depression and anxiety. It is also used for pain caused by nerve damage associated with diabetes (diabetic peripheral neuropathy).

Duloxetine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). It works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.

Nausea, dry mouth, constipation, loss of appetite, tiredness, drowsiness, or increased sweating may occur. If any of these effects last or get worse, tell your doctor promptly. Dizziness or lightheadedness may occur, especially when you first start or increase your dose of this drug.

Cymbalta can help to alleviate symptoms of depression, anxiety, and chronic pain. Like other SNRIs, Cymbalta works by increasing the amount of serotonin and norepinephrine in the brain to improve mood, decrease anxiety, and reduce pain perception.

Cymbalta has many potential side effects, some of which can be severe, including an elevated risk of suicide and serotonin syndrome. You can develop an addiction or tolerance to this drug. Stopping Cymbalta suddenly can result in withdrawal symptoms.

Cymbalta is a commonly prescribed Antidepressant used to treat generalized anxiety disorder and depression. Although generally considered nonaddictive, Cymbalta presents a high risk for abuse and dependence.

Cymbalta inhibits the reuptake of serotonin and norepinephrine in the central nervous system. It also increases dopamine by acting on dopamine reuptake pumps, thus increasing the diffusion of dopamine in the brain.

Long-term use of Cymbalta is safe for most people. Essentially, once you're past the initial one- to four-week period necessary for the medication to begin to work, many people find side effects taper off…with one possible exception.

Research has found that short-term Cymbalta effects are generally found to continue and intensify after long-term Cymbalta use. Chronic and life-threatening adverse reactions include liver failure, which can increase with alcohol use. Other serious effects include the increased risk of bleeding events.

Some people who take Cymbalta say it helps improve their mood and decrease pain. But some also report that the medication blunts their emotions.

Like most antidepressants, Cymbalta may trigger suicidal thoughts and behavior in children, adolescents and adults under the age of 24. Therefore, patients should be monitored closely for changes in mood and behavior and the emergence of such symptoms.

Are There Any Risks For Taking Duloxetine For Long Periods Of Time? To date, there are no known problems associated with long term use of duloxetine. It is a safe and effective medication when used as directed.

While duloxetine works well to improve mood and increase motivation in mental health conditions it has also shown efficacy in reducing chronic pain. It is thought that duloxetine works for pain in the same way it works for mental health; by increasing the amount of circulating serotonin and norepinephrine.

In some cases, your doctor may stop prescribing Cymbalta. You may also choose to stop taking it if you've found that it's no longer effective or it's causing side effects. However, when you stop taking Cymbalta, it can trigger withdrawal side effects.