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What is Dupixent (Asthma) Dupixent?

Dupixent (dupilumab) for Asthma

Dupixent (dupilumab) is a medication used for the treatment of moderate-to-severe asthma in both adult and pediatric patients aged 6 years and older. It is an add-on maintenance treatment that can be used in individuals whose asthma is characterized by specific features.

Mechanism of Action

Dupixent works by inhibiting the signaling of two proteins called interleukin-4 (IL-4) and interleukin-13 (IL-13). These proteins play a role in the immune system and are known to be involved in the development of allergic diseases such as asthma. By blocking the IL-4 and IL-13 signaling pathways, Dupixent helps to reduce inflammation and limit airway hyperresponsiveness in asthma patients.

Clinical Use

Dupixent is intended for use in individuals with moderate-to-severe asthma who require additional treatment despite using high-dose inhaled corticosteroids, long-acting beta-agonists, or other asthma controller medications. It is not used as a rescue medication for acute asthma symptoms.

Efficacy and Safety

The efficacy and safety of Dupixent for asthma treatment have been evaluated in clinical trials. These trials have shown that Dupixent can significantly improve lung function, reduce the rate of exacerbations, and improve asthma control compared to placebo in patients with uncontrolled moderate-to-severe asthma. Some patients may experience improvement in asthma symptoms within a few weeks of starting treatment.

Common side effects of Dupixent include injection site reactions, sore throat, headache, and an increase in eosinophils (a type of white blood cell). Serious side effects, although rare, may occur and should be reported to a healthcare professional promptly.

Prescription and Administration

Dupixent is available as an injectable medication that is administered subcutaneously (under the skin). It is typically given once every two weeks or once every four weeks, depending on the individual's age, weight, and specific treatment plan determined by their healthcare provider. The injection can be self-administered or given by a healthcare professional.

To ensure the safe and effective use of Dupixent, it is important to follow the instructions provided by the prescribing healthcare professional and the product labeling. Regular follow-up appointments with the healthcare provider are recommended to monitor the response to treatment and manage any concerns or side effects.

Conclusion

Dupixent (dupilumab) is a medication approved for the treatment of moderate-to-severe asthma in individuals aged 6 years and older. It works by targeting specific proteins involved in the immune response, resulting in a reduction of inflammation and improved asthma control. While Dupixent has shown efficacy in clinical trials, it is important to consult with a healthcare provider for an accurate assessment of its potential benefits and risks based on individual patient characteristics. Regular follow-up and monitoring are essential for the successful management of asthma with any medication.

Frequently Asked Questions about dupixent (asthma) dupixent

DUPIXENT is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in adults and children 6 years of age and older whose asthma is not controlled with their current asthma medicines.

DUPIXENT is a prescription medicine used: to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies.

Development timeline for Dupixent

DateArticle
Oct 19, 2018Approval FDA Approves Dupixent (dupilumab) for Moderate-to-Severe Asthma
Mar 28, 2017Approval FDA Approves Dupixent (dupilumab) for Eczema
Sep 26, 2016Sanofi and Regeneron Announce Dupilumab Biologics License Application Accepted for Priority Review by U.S. FDA

Not a Steroid. DUPIXENT is something different: the only dual-targeting biologic treatment for moderate-to-severe asthma. It's taken by injection under the skin (subcutaneous injection). It is taken differently than oral steroids and inhalers.

In the U.S., Dupixent is approved as an add-on maintenance treatment of patients aged 6 years and older with moderate-to-severe asthma characterized by an eosinophilic phenotype or with oral-steroid dependent asthma; in patients aged 6 years and older with uncontrolled moderate-to-severe atopic dermatitis; and for use ...

Dupixent's cost may also be higher because it's an injectable medication and may only be available through specialty pharmacies. And in some cases, you need to visit your doctor to receive a dose. To learn more about ways to save on the cost of Dupixent, see the “Can I get help paying for Dupixent?” section below.

Dupixent works on two interleukins thought to contribute to atopic diseases: IL-4 and IL-13. By blocking IL-4 and IL-13 from binding to the receptors, Dupixent curbs the immune system over-reaction that results in atopic dermatitis. A calmed immune system leads to fewer and/or less severe symptoms of AD.

Dupixent is FDA-approved for multiple indications, including treatment of atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyposis, and eosinophilic esophagitis.

Generic Name: dupilumab Dupilumab belongs to a class of drugs known as monoclonal antibodies. It works by blocking certain natural proteins in your body (interleukin-4 and interleukin-13) that may cause inflammation and swelling. This medication should not be used to relieve sudden asthma attacks.

Serious hypersensitivity reactions (such as serum sickness and urticaria) have been reported in less than 1% of people administered Dupixent. If a reaction occurs, discontinue Dupixent and initiate appropriate treatment. There is also the potential for immunogenicity and antibody formation.

Use DUPIXENT exactly as prescribed by your healthcare provider. It's an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT.

Dupixent is FDA-approved to treat certain forms of moderate to severe atopic dermatitis in adults and children ages 6 months and older. Atopic dermatitis, commonly known as eczema, is a chronic skin condition that can make your skin discolored, swollen, dry, and itchy.

Dupixent works on two interleukins thought to contribute to atopic diseases: IL-4 and IL-13. By blocking IL-4 and IL-13 from binding to the receptors, Dupixent curbs the immune system over-reaction that results in atopic dermatitis. A calmed immune system leads to fewer and/or less severe symptoms of AD.

Biologics – Dupilumab, is the first biologic injection available in Singapore for treating severe atopic dermatitis.

TV spots

TV commercials Dupixent (Asthma) Dupixent

Dupixent (Asthma) TV Spot, 'Disfrutar más'
Dupixent (Asthma) TV Spot, 'Disfrutar'
Dupixent (Asthma) TV Spot, 'Du More: Kick Boxing'
Dupixent (Asthma) TV Spot, 'It's Possible: Water Slide, Groceries, Kites'
Dupixent (Asthma) TV Spot, 'Jugar al aire libre'
Dupixent TV Spot, 'Better Breathing'
Dupixent TV Spot, 'Du More: Commuter'
Dupixent TV Spot, 'DU More: Diving Board, Soccer and Playground'
Dupixent TV Spot, 'Du More: Teacher'
Dupixent TV Spot, 'Du More: Yard Work & Team Work'
Dupixent TV Spot, 'Du-More: Surprise Party and Baking'
Actors

Actors who starred in Dupixent (Asthma) Dupixent commercials

Holly Burr photo
Advertisers

Advertisers of commercials featuring Dupixent (Asthma) Dupixent

Dupixent (Asthma) Dupixent commercials
Dupixent (Asthma)

Dupixent is a medication used in the treatment of asthma. It is a brand name for the drug dupilumab , which is manufactured by the pharmaceutical companies Sanofi and Regeneron. Dupixent is an inject...

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