Humira is presented as a vial, or a single-use prefilled syringe, containing 40 mg of active substance in 0.8 ml of a buffered solution comprised of mannitol, citric acid monohydrate, sodium citrate, disodium phosphate dihydrate, sodium dihydrogen phosphate dihydrate, sodium chloride, and Polysorbate 80.

The drug suppresses the immune system by blocking the activity of TNF. TNF is a protein produced naturally by the body's immune system. Some people with certain autoimmune diseases produce too much TNF. Humira is designed to stop tumor necrosis factor-α, or TNF, from attacking healthy cells.

HUMIRA is a prescription medication that targets and blocks a source of inflammation caused by moderate to severe ulcerative colitis (UC). It is administered by injection under the skin. You can administer it yourself, either by Pen or syringe, in the comfort of your own home.

Humira contains the active drug adalimumab, which is a biologic medication. Biologics are medications made from living cells. Adalimumab belongs to a class of medications known as tumor necrosis factor (TNF) blockers. (A class of medications is a group of drugs that work in a similar way.)

“Humira (D2E7, adalimumab) was originally developed through a joint venture between Cambridge Antibody Technology and BASF in the UK,” she explains. “In 2000, Abbott acquired the pharmaceutical segment of the German chemical company BASF for $6.9bn.

The brand name Humira stands for "human monoclonal antibody in rheumatoid arthritis", and was named by one of Abbott's employees, Richard J. Karwoski, who was also responsible for leading the effort to get Humira approved by the FDA.

Through its savvy but legal exploitation of the U.S. patent system, Humira's manufacturer, AbbVie, blocked competitors from entering the market. For the next six years, the drug's price kept rising. Today, Humira is the most lucrative franchise in pharmaceutical history.

Humira (adalimumab) is a medication that is used over the long-term. Your doctor will check your medication at regular intervals to be sure staying on Humira is appropriate for you. Your dose for Humira can also vary and depends on the condition being treated. However, many patients stay on Humira for many years.

There are risks in taking Humira, especially as it interferes with the body's ability to fight infections. However, it is effective in treating symptoms of Crohn's and can help a person remain in remission. There are various potential risks and side effects of the medication, most of which relate to signs of infection.

HUMIRA mechanism of action Adalimumab targets and blocks a source of inflammation by binding specifically to TNF alpha, an inflammation-causing protein, which helps to reduce the inflammation in the body that can lead to ulcerative colitis symptoms.

It is what's known as a biologic. Typically, patients must have an inadequate response to conventional medications to be considered for biologics. More specifically, Humira is a tumor necrosis factor-α blocker, or TNF blocker. The drug suppresses the immune system by blocking the activity of TNF.

Why Humira Biosimilars Now? Humira brought in more than $20 billion in 2021 for its manufacturer, AbbVie.