It is used to treat traveler's diarrhea and irritable bowel syndrome with diarrhea. It is also used to prevent hepatic encephalopathy, a brain disorder that can occur due to severe liver disease. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

XIFAXAN tablets contain rifaximin, a non-aminoglycoside semi-synthetic, nonsystemic antibiotic derived from rifamycin SV. Rifaximin is a structural analog of rifampin. The chemical name for XIFAXAN tablets for oral administration are film-coated and contain 200 mg or 550 mg of rifaximin.

Rifaximin is a semisynthetic derivative of rifamycin [1, 2] that was first approved in Italy in 1987, was approved as Xifaxan (Salix Pharmaceuticals) by the US Food and Drug Administration (FDA) in 2004 for the treatment of uncomplicated traveler's diarrhea [3], and is currently approved for use in 17 countries [4].

Xifaxan (rifaximin) is a rifamycin antibiotic. It works by stopping bacteria from making important proteins they need to survive.

INDICATIONS. XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

The cost for Xifaxan oral tablet 550 mg is around $3,337 for a supply of 60 tablets, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.

Most voted positive review The bad bacteria took over my intestines, resulting in pain and explosive diarrhea. After a colonoscopy and other antibotic treatments for 3 months I was prescribed the Xifaxan. The symptoms started to clear within a week.

Recommended by the American College of Gastroenterology *In clinical trials, more patients taking XIFAXAN vs. placebo for 2 weeks had relief of IBS-D symptoms for 10 weeks following treatment. Median duration of symptom relief was 10 weeks (range of 6 to 24 weeks). You can be retreated up to 2 times if symptoms return.

XIFAXAN has a well-established Safety Profile Constipation was observed in 0.3%-0.6% of patients treated with XIFAXAN. Nausea was observed in 3% of patients taking XIFAXAN vs 2% taking placebo. Liver enzymes increase observed in 2% of patients taking XIFAXAN vs 1% taking placebo.

If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.

Mild side effects that have been reported in people taking Xifaxan for irritable bowel syndrome with diarrhea include: high level of liver enzymes, which could be a sign of liver damage.

Side effects include: Hepatic encephalopathy: Peripheral edema, nausea, dizziness, fatigue, ascites, muscle spasms, pruritus, abdominal pain, anemia, depression, nasopharyngitis, upper abdominal pain, arthralgia, dyspnea, pyrexia, rash. IBS with diarrhea: Nausea, increased ALT concentrations.

Xifaxan (rifaximin) and lactulose solution are used to treat or prevent complications of liver disease (hepatic encephalopathy). Xifaxan is also used to treat patients 12 years of age and older with travelers' diarrhea caused by noninvasive strains of Escherichia coli (E. coli).