The main differences between the two are the strength and speed at which the products work, with Simparica killing fleas in little as 3 hours and ticks within 8. Nexgard offers a 4 hour time frame for killing fleas while killing ticks in 24 hours.

Simparica Trio is considered safe for dogs as young as eight weeks old who weigh at least 2.8 pounds. However, the product has not been evaluated in breeding, pregnant, or lactating dogs.

for 35 days Simparica is a monthly chewable that protects your dog for 35 days. That means you have a little wiggle room at the end of the month.

Simparica Trio is a parasite preventative used to protect your pet from fleas, ticks, and other parasites. While it's generally well-tolerated by dogs, pet parents should discuss the potential side effects and Simparica Trio alternatives with their vet beforehand.

If you have a breeding dog, a pregnant dog, or a puppy between 6 and 8 weeks old, Heartgard Plus is the safest option. If you're hoping to find a broad-spectrum product that protects against fleas and ticks while it defends against internal parasites, Simparica Trio is the clear winner.

The generic active ingredient for Simparica is Sarolaner. How Is It Given? Simparica can be given to your dog any time of the day, however it is recommended that you give your dog the chew during mealtime or with food.

Here's what you should know. The FDA recently released an alert that reads: “The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats.” but went on to warn pet owners and veterinarians about potential neurological reactions to the isoxazoline class of drugs.

If chemical products are necessary for additional flea or tick control, NRDC recommends s-methoprene or pyriproxyfen, which are less toxic ingredients - but read the labels carefully because some products use them with other, more harmful pesticides.

Simparica (sarolaner) is a chewable, once a month preventative that can provide continuous protection against fleas, ticks, and tick borne pathogens. How does Simparica work? With a highly palatable liver flavor, your dog ingests this once a month chewable to begin flea and tick protection.

Simparica flea and tick medicine are proven to be 96.9 percent effective at killing fleas and ticks in dogs, and it starts working in three to eight hours after the first tablet. If your dog has a flea infestation, the medication will kill the existing fleas and prevent new infestations on your pet.

Since these products have obtained their respective FDA approvals, data received by the agency as part of its routine post-marketing activities indicates that some animals receiving Bravecto, Nexgard or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.

If you're looking for a monthly preventive that protects your pet from heartworm, ticks, fleas, and intestinal worms, NexGard SPECTRA is a common, cheaper alternative to Simparica Trio.