PetArmor Plus Flea and Tick Topical For Extra-Large Dogs 89-132 lbs., 12 weeks and older is a waterproof, fast-acting, long-lasting formula that kills adult fleas and ticks plus stops the flea cycle dead in its tracks. This dog flea treatment has the same active ingredients as FRONTLINE® Plus for Dogs.

Kills chewing lice in dogs and puppies and controls mites that may cause sarcoptic mange. Kills fleas and ticks with the same efficacy as Frontline Top Spot.

There are several Frontline products: Shield, Plus, and Gold. Our top choice for an OTC flea preventive is Frontline Plus, which also protects against chewing lice and helps control sarcoptic mange infestations.

Frontline Plus Our top choice for an OTC flea preventive is Frontline Plus, which also protects against chewing lice and helps control sarcoptic mange infestations. Compared to Frontline Plus, NexGard kills fleas more quickly (4 hours versus 12 hours) and ticks (24 hours versus 48 hours).

Both Advantage and Frontline are effective against fleas and ticks, but they have different active ingredients and modes of action. Advantage contains imidacloprid, which kills fleas on contact, while Frontline contains fipronil, which spreads through the oils of the skin and hair follicles to kill fleas and ticks.

Frontline Spray provides long-lasting, effective control of fleas and ticks on your pet. It kills up to 100% of existing fleas in less than 24 hours. Frontline Spray continues killing fleas for an entire month or more.

Among the best flea treatments for dogs, Frontline Plus is our top nonprescription recommendation because it kills ticks and fleas, controls flea infestations, and kills chewing lice, all with one easy application. When used primarily for flea control, each dose of Frontline Plus lasts up to three months.

Under many circumstances, newer dog flea collars are safe options for flea and tick control (unlike older collars, which were largely ineffective). The Seresto collar is a very popular and effective option. It uses flumethrin and imidacloprid to kill fleas at multiple stages of development, and kills ticks as well.

If you are concerned about fleas and ticks then Frontline Plus for Dogs is the product, but if you are looking for protection against only fleas Advantage would work best.

Find What Works for Your Pet If you are looking for a good alternative flea treatment at an affordable price for your cat or dog, the fipronil Frontline alternatives may be a good choice. Other quality alternatives to fipronil include sarolaner and Bravetco (which are effective for three months).

Topical fipronil and S-methoprene applied to cats still kills more than 95% of fleas within 24 hours, 28 days after application (3). However, after this time the efficacy does begin to drop, allowing fleas to survive long enough to reproduce.

Frontline Side Effects There are many concerns about possible side effects, the most common being skin reactions like hair loss, itching, and redness, and neurological issues like uncoordinated movement and lethargy. However, these side effects are not addressed anywhere on the US website for Frontline.