"What I'm working on with my doctor is a plan that includes exercising, eating right and taking a medicine called Prolia® along with calcium and vitamin D," said Danner. "Every woman is different, and I encourage women to work with their doctors on a plan that is right for them."

Blythe Danner Blythe Danner appears in this Prolia commercial as a spokeswoman saying that it helps with post-menopausal osteoporosis.

The U.S. Food and Drug Administration (FDA) is investigating the risk of severe hypocalcemia with serious outcomes, including hospitalization and death, in patients with advanced kidney disease on dialysis treated with the osteoporosis medicine Prolia (denosumab).

Fosamax is usually the first-choice option for osteoporosis. But Prolia may be preferred in people with very high fracture risk. The most common side effects of Boniva and Fosamax are gastrointestinal symptoms like acid reflux, nausea, and diarrhea.

(Reuters) - Amgen Inc sued Novartis AG's Sandoz in New Jersey federal court Monday, accusing Sandoz's proposed versions of its multibillion-dollar bone-strengthening drugs Prolia and Xgeva of infringing several patents. Amgen asked the court to block Sandoz's biosimilars of the drugs until its patents expire.

Prolia can sometimes cause harmful effects in people who have certain conditions. This is known as a drug-condition interaction. Other factors may also affect whether Prolia is a good treatment option for you. Talk with your doctor about your health history before you take Prolia.

This drug has a long list of side effects and it's also important to note that long-term risks are unknown. The FDA Medication Guide lists the potential health problems, which include serious infections, thighbone fractures, and jaw bone problems. It is unclear if the benefits outweigh the risks.

Medication is standard for treating osteoporosis, although there are lifestyle changes you should make, too. For example, eating healthy, walking, resistance training, and ensuring adequate vitamin D stores as well as daily intake of calcium can all help improve bone mineral density.

How long can I stay on Prolia for? For Prolia to work well at reducing fractures it needs to be taken long term and in one phase 2 clinical trial it has been used safely for up to 8 years with substantial increase in bone density, although most clinical trials are for 3 or 4 years.

Prolia's therapeutic benefits, on the other hand, don't continue after treatment is stopped. And an abrupt discontinuation of Prolia without following it with an antiresorptive agent (like a bisphosphonate) is associated with a rebound effect that can lead to bone loss and fractures, says Moseley.

How long can I stay on Prolia for? For Prolia to work well at reducing fractures it needs to be taken long term and in one phase 2 clinical trial it has been used safely for up to 8 years with substantial increase in bone density, although most clinical trials are for 3 or 4 years.

How long can I stay on Prolia for? For Prolia to work well at reducing fractures it needs to be taken long term and in one phase 2 clinical trial it has been used safely for up to 8 years with substantial increase in bone density, although most clinical trials are for 3 or 4 years.